Messaggio et al. reported that AdipoR increases apoptotic positive cells in human and mouse pancreatic cancer [29], whereas Akimoto et al. demonstrate that AdipoR-treated MIA PaCa-2 cells die largely via RIPK1-dependent necroptosis and mitochondrial dysfunction-mediated autophagy [28]. This evidence concerns the gene RIPK1 and familial pancreatic carcinoma.