RAF1 fusion was detected in 4 cases (GC, melanoma, STS, and pancreatic cancer), BRAF fusion in 2 cases (BTC and STS), ALK fusion in 2 cases (CRC and BTC), ROS1 fusion in 1 case (CRC), and EGFR fusion in 1 case (CRC) with diverse counterparts. The gene discussed is EGFR; the disease is familial pancreatic carcinoma.