An interesting study has described the H3K4me3 and H3K27me3 as a mark of the glioblastoma cell tumorigenicity linked to the network of the transcription factors [3], pointing the involvement of the hypoxia-inducing factor (HIF) family member aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) in the modulation glioblastoma cell aggressiveness. Here, ARNT2 is linked to glioblastoma.