The impairment of major anabolic systems (somatotropic, adrenal, and gonadal) does not appear to represent a mere epiphenomenon but is involved in the CHF pathophysiology; especially low serum testosterone (T), dehydroepiandrosterone-sulfate (DHEA-S), and insulin-like growth factor (IGF)-1 levels have been correlated to the symptoms severity and the adverse outcomes in men suffering from CHF [15–19]. The gene discussed is IGF1; the disease is congestive heart failure.