INS and Hypoglycemia: No differences were observed in postprandial AUC of plasma glucagon concentrations after test meals consumption in both study and control groups, irrespective of BMI and higher fasting and postprandial glucagon concentrations observed in men; however, the influence of sex on glucagon is not well established as some investigators showed higher insulin-induced concentrations in men with comparable fasting levels suggesting enhanced counterregulatory effects [28–31], whereas others found no differences in fasting and exercise [32] or hypoglycaemia-induced glucagon concentrations [33].