To test whether both the polymorphisms of adiponectin gene, rs2241766 and rs1501299 genotypes, are associated with depression symptoms of isotretinoin, depression status was compared among genotypes in rs2241766 TT and TG/GG (Pp value = 0.066) and in rs1501299 GG and GT (P value = 0.052). This evidence concerns the gene ADIPOQ and depressive disorder.