However, there are conflicts about the role that hepatic PPARγ plays in the development of MCD-induced steatohepatitis since adenovirus-mediated overexpression of PPARγ with a cytomegalovirus promoter (not hepatocyte-specific) reduces fibrosis and steatosis [22, 23] in mice fed an MCD diet. The gene discussed is PPARG; the disease is steatosis.