Despite steatosis observed in MCD-fed mice is thought to be promoted by enhanced lipid uptake, in part, due to increased hepatocyte PPARγ and CD36 expression, our data suggested that PPARγ and/or CD36-dependent lipid uptake is not a major mechanism required for the development of steatosis in a model of steatohepatitis induced by the MCD diet. The gene discussed is PPARG; the disease is steatosis.