For the in vitro and in vivo therapeutic potential of IL-37b on AD with its underlying mechanism of eosinophil-Th2 axis, the activation of autophagy-related AMPK-mTOR signaling pathway in eosinophil-dermal fibroblast co-culture and MC903-mediated AD like mice model, as well as the regulation of gut microbiota-immunity interaction were herein confirmed. The gene discussed is PRKAA1; the disease is Alzheimer disease.