We here set out to dissect the antibody responses induced by the initial combined HIVIS-DNA/MVA-CMDR vaccination and the late third MVA-CMDR boost in more detail to elucidate whether the HIVIS03/06 vaccination schedule can induce and sustain antibody responses to HIV-1 Env epitopes associated with reduced infection risk in RV144 (9, 10). Here, ERVW-1 is linked to infection.