Other types of type-I interferonopathies, such as systemic lupus erythematosus (SLE) and Aicardi–Goutières syndrome (AGS), have relationships with defective clearance of cytosolic nucleic acids caused by congenital dysfunction of TREX1, RNASEH2, and SAMHD1. This evidence concerns the gene TREX1 and Aicardi-Goutieres syndrome.