SAMHD1 and Aicardi-Goutieres syndrome: Other types of type-I interferonopathies, such as systemic lupus erythematosus (SLE) and Aicardi–Goutières syndrome (AGS), have relationships with defective clearance of cytosolic nucleic acids caused by congenital dysfunction of TREX1, RNASEH2, and SAMHD1.