HSPA12B and Sepsis: Figure 1C shows that EC HSPA12B deficiency accelerates mortality of CLP septic mice. The time to 50% mortality in WT septic mice was 56 h, and 100% occurred at 100 h after induction of CLP-sepsis. In HSPA12B–/– septic mice, however, the time to 50% mortality was 40 h. The mortality reached to 100% was 60 h after induction of CLP sepsis (P < 0.01).