Figures 2F,G show that CLP sepsis increased the immunostaining of VCAM-1 (F) and ICAM-1 (G) in the myocardium of WT mice. However, there is more positive immunostaining for VCAM-1 and ICAM-1 in the myocardium from HSPA12B–/– septic mice than in WT septic mice. Western blot analysis shows that CLP sepsis markedly increased the levels of myocardial VCAM-1 (Figure 2H) and ICAM-1 (Figure 2I) in WT mice. The levels of myocardial VCAM-1 and ICAM-1 in HSPA12B–/– septic mice were further increased 173 and 191%, respectively, when compared with WT septic mice. Here, HSPA12B is linked to Sepsis.