Additionally, we can suggest that the increased content of catecholamines do not mean increased adrenal medulla secretion, as we did not observe any differences in catecholamines plasma levels (Figures 3A,B) and that is not key to the maintenance of insulin resistance, as HSu animals with adenosine receptors blocked exhibit high Epi/NE adrenal medulla content but normalized levels of insulin sensitivity. Here, INS is linked to Insulin resistance.