For example, do any of the niche cells of the liver such as HSCs and LSECs which express higher levels of Igfbp7 than Res-KCs under homeostatic conditions (unpublished data) also express Igfbp7 in NAFLD/NASH and what role does this play? The gene discussed is IGFBP7; the disease is metabolic dysfunction-associated steatohepatitis.