However, as here there was no discrimination between Res-KCs and other liver macs (59) it is difficult to draw any conclusions regarding the roles of these cells, perhaps Res-KCs are not activated or perhaps they are but their numbers are reduced in NAFLD leading to the majority of total macs being Temp-macs without an overtly activated profile. The gene discussed is TBCE; the disease is metabolic dysfunction-associated steatotic liver disease.