As the relationship between the two KC subsets identified in the ALMN-fed mice was not studied (27), it is not clear if the NAMs represent a recruited population of infRes-KCs, while the non-NAM KCs represent Res-KCs that do not alter their phenotype in NASH or if the NAMs are a population of Res-KCs that have altered their transcriptome due to the NASH environment. This evidence concerns the gene CALCA and metabolic dysfunction-associated steatohepatitis.