A study in human cervical squamous carcinoma reported that miR-22-3p causes inhibition of cell apoptosis by targeting the eIF4EBP3 gene (13) and suppresses cell proliferation in hepatocellular carcinoma and arterial smooth muscle by regulating SP1 and HMGB1, respectively (14, 15). Here, HMGB1 is linked to hepatocellular carcinoma.