Previous studies have shown that miR-486-5p plays a role as a tumor suppressor of nonsmall cell lung cancer (NSCLC) (1), hepatocellular carcinoma cells (2), and leukemia cells, where it induces apoptosis by targeting FOXO1 (3); it also prevents the migration, invasion, and endothelial-to-mesenchymal transition (EMT) by regulating Smad2 in breast cancer (4). This evidence concerns the gene SMAD2 and hepatocellular carcinoma.