For example, Keren-Shaul et al. (2017) used the 5XFAD murine model of AD to define Disease Associated Microglia (DAMs) that express a distinct set of genes associated with lipid and lipoprotein metabolism (e.g., Apolipoprotein E [ApoE], Lipoprotein Lipase [LPL], and Triggering Receptor Expressed On Myeloid Cells 2 [TREM2]) (Keren-Shaul et al., 2017). This evidence concerns the gene APOE and Alzheimer disease.