APOE and Alzheimer disease: Similarly, scRNA-seq studies have shown that microglia express higher levels of ApoE in the embryonic mouse brain (E14.5) (Hammond et al., 2019), during LPC mediated demyelination injury (Hammond et al., 2019), and in the late stages of disease pathogenesis in murine models of AD (Keren-Shaul et al., 2017).