Protein kinase D1 (PKD1) mediates the processes of myocardial remodeling, angiogenesis and myocardial contraction (Ren, 2016; Serocki et al., 2018), but the mechanism of PKD1 in the processes of the inflammatory response and cell injury in the microenvironment after myocardial infarction has not been determined. Here, PKD1 is linked to myocardial infarction.