Former studies, aimed at investigating the role of TRAP1 in cancer, highlighted that it is overexpressed in several tumor tissues (if compared with peer non-tumor counterparts) and suggested that this phenomenon was linked to TRAP1 ability to rewire metabolism and favor the “Warburg effect” (Sciacovelli et al., 2013; Masgras et al., 2017a,b; Matassa et al., 2018). This evidence concerns the gene TRAP1 and neoplasm.