TRAP1 and neoplasm: These assumptions have been redefined in the last few years as: i) some tumors are not fully glycolytic but, depending on environmental availability of nutrients, can interchangeably use OXPHOS to sustain their accelerated growth, and ii) TRAP1 has been found differentially expressed in different tumors—and in different stages within the same tumor—in order to adjust metabolism to tumor cell needs (Matassa et al., 2018).