In addition, many reports of colorectal tumor cells either overexpressing COX-2 or having it silenced have correlated increased COX-2 expression with their invasive and metastatic properties in xenografted tumors in mice (Tsujii and Dubois, 1995; Tsujii et al., 1997; O’mahony et al., 1999; Chen et al., 2001; Sun et al., 2002; Yoshimoto et al., 2002; Charames and Bapat, 2006; Strillacci et al., 2006; Stamatakis et al., 2015). The gene discussed is PTGS2; the disease is colorectal neoplasm.