Moreover, there is a positive feedback loop between COX-2 and PGE2, in which COX-2 induces PGE2 production, and that in turn increases further the expression of COX-2 in colon cancer cells (Stamatakis et al., 2015; Karpisheh et al., 2019). Here, PTGS2 is linked to malignant colon neoplasm.