We found NFAT5 is induced by COX-2 overexpression and it has been described that promotes metastasis through the induction of alpha(6)beta(4) integrin in human breast and colon tumors (Jauliac et al., 2002), and besides some associations between NAFT5 SNPs and CRC risk has been found (Slattery et al., 2011). This evidence concerns the gene PTGS2 and colorectal carcinoma.