PMEPA1 and ovarian cancer: A recent study using colon cancer cell lines revealed the role of PMEPA1 in cell migration and invasion through bone morphogenetic proteins (BMP) signaling pathway activation and phosphorylation of the transcription factors Smad1 and Smad5 (Zhang et al., 2019), which also correlates with its described effect in ovarian cancer cells (Jimenez-Segovia et al., 2019).