HPGD and colorectal carcinoma: In addition it has also been described that the lack of the enzyme 15-PGDH, responsible for the inactivation of prostaglandins and lipoxins, is associated with CRC (Backlund et al., 2005) and together with the increase in the PGE2 synthesis, induces tumor formation in Min (multiple intestinal neoplasia) CRC model in mice.