Recent studies, remark the role of COX-2 in constitutive IDO1 expression by human tumors and substantiate the use of COX-2 inhibitors to improve the efficacy of cancer immunotherapy, either by reducing constitutive IDO1 expression, which contributed to the lack of T-cell infiltration in tumors that fail to respond to immunotherapy (Hennequart et al., 2017), or by synergizing with anti-checkpoint antibodies (Zelenay et al., 2015). The gene discussed is PTGS2; the disease is cancer.