Aldosterone stimulates the renal salt reabsorptions via MR-induced Sgk1 expression; whereas elevated MR-Sgk1 signaling was associated with the pathogenesis of kidney fibrosis and hypertension (Lang et al., 2000; Terada et al., 2005; Kawarazaki et al., 2012). The gene discussed is NR3C2; the disease is hypertensive disorder.