Also from Scutellaria baicalensis Georgi, wogonoside (100 mg/kg/d for 15 weeks) was reported to increase the survival rate of AOM/DSS-induced CAC mice by decreasing tumor number, tumor size, average tumor load, and occurrence of large-sized adenomas through the reduction of NF-κ B p65, p-p65, PI3K, p-Akt, cyclin D1, and survivin levels, as well as cytokine secretion in tumor tissue (Sun et al., 2016). This evidence concerns the gene AKT1 and neoplasm.