TP53 and infectious otitis media: In the study of Lin et al., SBS (7.28 g/kg for 15 weeks) administration was able to significantly down-regulate the levels of neoplastic markers such as PCNA, β-catenin, and p53 as well as TGF-β1 and Wnt5a in a mouse model of CAC established by AOM/DSS treatment (Lin et al., 2015).