The underlying molecular mechanism included its inhibitory effect on STAT phosphorylation as well as the expressions of Bcl-2 and cyclin D. Besides, the Bax level was elevated after oroxylin A administration, suggesting that oroxylin A induced apoptosis through modulating the IL-6/STAT3 pathway in ADM/DSS-elicited mouse colitis-associated carcinogenesis (Yang et al., 2013). This evidence concerns the gene STAT3 and colitis.