CCND1 and neoplasm: Extracted from another famous herbal medicine named Curcuma longa L., curcumin (25 mg/kg/day for 62 days) promoted the accumulation of cells in G0/G1 phase and subsequently induced tumor cell apoptosis by regulating targets that involved WNT/β-catenin like cyclin D1 in AOM/DSS-challenged mice (Marjaneh et al., 2018).