In the study, AOM/DSS induced CRC mice were fed an AIN93G diet supplemented with nobiletin (0.05 wt% in diet for 20 weeks), after which the incidence and multiplicity of colonic tumors were reduced, and there were also reductions in expression of iNOS and protein levels of cyclin D, CDK6, CDK4, and CDK2 and increased levels of p27 and p53 (Wu et al., 2017). Here, CDK4 is linked to colonic neoplasm.