TLR4 and colitis: The essential oil and pericarp of ZBM have been demonstrated to have a positive impact on experimental colitis via the regulation of the NF-κ B/PPAR-γ and TLR4-related signaling pathways, respectively (Zhang Z. et al., 2016; Zhang Z. et al., 2017), suggesting its great potential to be a CAC-ameliorative candidate.