CASP3 and malignant colon neoplasm: A study conducted by Kim et al. demonstrated that administration of baicalein (1–10 mg/kg for 14 weeks) from Scutellaria baicalensis Georgi downregulated expressions of pro-caspase-3/8 so as to induce HCT-116 apoptosis through extrinsic means in a mouse model of colitis-driven colon cancer (Kim D. H. et al., 2013).