Previous studies have reported on the application of a sensitive immunomagnetic reduction-based immunoassay (IMR), which can quantitatively detect plasma biomolecules of Aβ-40, Aβ-42, and T-tau at ultra-low concentrations for the early detection of cognitive impairment (Yang et al., 2011; Chiu et al., 2014). Here, MAPT is linked to Cognitive impairment.