Similarly, LRRK2 appeared crucial for the antibacterial activity of macrophages during infection with Salmonella typhimurium in vitro (Gardet et al., 2010), which was confirmed in vivo using mice lacking LRRK2 (Gardet et al., 2010; Liu et al., 2017; Shutinoski et al., 2019). Here, LRRK2 is linked to infection.