LRRK2 and Parkinson disease: Approximately 10% of all PD cases have a monogenic origin, with mutations in genes encoding for α-synuclein (SNCA), Leucine-Rich Repeat Kinase 2 (LRRK2), Parkin, PTEN-induced putative kinase 1 (PINK1), or DJ1 as the most studied examples (Nuytemans et al., 2010).