LRRK2 and Parkinson disease: The evidence that WT LRRK2 is not only involved in PD-related neuroinflammation is underlined by the finding that suppressing LRRK2 activity or expression is also protective against neuroinflammation after exposure to manganese (Chen et al., 2018) or HIV-1 Tat protein in an HIV-1 associated neurocognitive disorder (HAND) model in vivo (Puccini et al., 2015).