TARDBP and amyotrophic lateral sclerosis: Finally, the link between ALS and FTD is also pathologic: the vast majority of ALS patients, whether of familial or sporadic origin, and as much as 45% of FTD patients present with the so-called TDP-43 pathology, i.e., toxic intra-cytoplasmic inclusions of a phosphorylated and misfolded form of the TDP-43 protein (Neumann et al., 2006; Ling et al., 2013).