Detailed analysis of the hypothalamus of ALS patients revealed the presence of TDP-43 pathology in 5/28 cases (Cykowski et al., 2014), suggesting that neurons of the tuberomammillary nucleus may not be a primary target of the TDP-43 pathology, and may maintain, in most cases their function. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.