SCN7A and amyotrophic lateral sclerosis: In the same study, Lederer et al. (2007) also reported on the down-regulation of KCNC2 (potassium voltage-gated channel subfamily C member 2), while similar microarray analyses conducted on motor and sensory cortex (Wang et al., 2009), or on motor cortex of ALS patients (Aronica et al., 2015) revealed the up-regulation of KCNIP2 (potassium voltage-gated channel interacting protein 2) and of SCN7A (sodium voltage-gated channel alpha subunit 7), respectively, further supporting altered neuronal excitability and action potential firing.