Firstly, decreased expression of low-density lipoprotein receptor-related protein 1 (LRP1) and P-glycoprotein (P-gp), together with increased expression of the receptor for advanced glycation end products (RAGE), is are observed in endothelial cells in AD patients (Yamazaki and Kanekiyo, 2017; Zenaro et al., 2017). Here, LRP1 is linked to Alzheimer disease.