OIP5 and cancer: Former works disclosed that lncRNA OIP5-AS1 was highly enriched in lung cancer [19], gastric cancer [20] and bladder cancer [21], performing as oncogene and predicting poor prognosis of cancer patients; and was downregulated in in basal-like tumors [22], cervical cancer [23] and MM [24], suggesting the dual functions of lncRNA OIP5-AS1 in human malignancies, which might be related to different tumor microenvironment.