NLRP3 and cryopyrin-associated periodic syndrome: Furthermore, it was confirmed that NLRP3 mutations occurred in many sites in the cells of patients with cryopyrin-associated cycle syndrome (CAPS), especially in the vicinity of ATP binding sites in Nacht domain [17]; therefore, new NLRP3 inhibitors (such as BAY 11-7082 and OLT1177) target this ATPase [18–20].