Increasing evidence has confirmed the association between the canonical and noncanonical functions of inflammasomes and kidney diseases, but many issues remain to be addressed, such as the effects of noncanonical caspase-11, caspase-4, and caspase-5 inflammasomes and other NLR genes; the role of pyroptosis; the activation of noncanonical inflammasomes in the kidney; and the function of gasdermin. Here, CASP4 is linked to kidney disorder.