In the Hepatic fibrosis model of mice that was induced by intraperitoneal injection of thioacetamide (TAA), the treatment of TSA lead to the lower expression of alpha-SMA, collagen I, TGF-beta1, Smad3 and IGFBP7 in liver, which implicated that TSA could improve liver function and inhibit the fibrosis through blocking TGF-β1/Smad3 signaling pathway30. Here, SMAD3 is linked to Hepatic fibrosis.