Consequently, LOX-1 combined with Ox-LDL not only promotes uptake of lipids, but also induces expression of inflammatory cytokines such as transforming growth factor-β(TGF-β), which stimulate the proliferation of HMCs and accelerate deterioration of kidney disease, suggesting that LOX-1 plays a key contributing role in progression of glomerulosclerosis 23. The gene discussed is TGFB1; the disease is glomerulosclerosis.