Furthermore, knockout of the NLRP5 and KHDC3L in female mice results in fertility defects, and human genetic mutations in these genes of the SCMC have been linked to infertility and molar pregnancies (Akoury et al., 2015; Li et al., 2008; Reddy et al., 2013; Wang et al., 2018; Zhang et al., 2019). This evidence concerns the gene NLRP5 and Infertility.