Autoimmune Polyglandular syndrome type 1 (APS1) or Autoimmune Polyglandular-Candidiasis-Ectodermal Dystrophy (APECED; OMIM #240300) is an autoimmune syndrome caused by monogenic mutations in the AIRE gene that result in defects in AIRE-dependent T cell education in the thymus (Aaltonen et al., 1997; Anderson et al., 2002; Conteduca et al., 2018; Malchow et al., 2016; Nagamine et al., 1997). The gene discussed is AIRE; the disease is autoimmune polyendocrine syndrome type 1.