KHDC3L and Infertility: Furthermore, knockout of the NLRP5 and KHDC3L in female mice results in fertility defects, and human genetic mutations in these genes of the SCMC have been linked to infertility and molar pregnancies (Akoury et al., 2015; Li et al., 2008; Reddy et al., 2013; Wang et al., 2018; Zhang et al., 2019).