Epigenome-wide association studies (EWAS) have found that hypermethylation within one of these genes involved in adipogenesis, ABCG1, was associated with increased body mass index (BMI), insulin resistance and T2D risk [12–15], opening avenues in the elucidation of the links between adipogenesis and metabolic diseases. This evidence concerns the gene ABCG1 and type 2 diabetes mellitus.