BACE1 and Alzheimer disease: Late phase clinical trials of other BACE1 inhibitors were recently terminated early or stopped for futility due to the lack of efficacy or for safety reasons, including studies of verubecestat (Merck, NJ, USA) in patients with mild-to-moderate AD (EPOCH study, NCT01739348) [15] and with amnestic MCI (APECS study, NCT 01953601) [18], and studies of lanabecestat (AstraZeneca, UK, and Eli Lilly IN, USA) in patients with MCI due to AD or mild AD dementia (AMARANTH NCT 02245737, DAYBREAK NCT02783573), [22].