Of course, geriatric aspects such as a potentially higher rate of side effects, especially myalgia and myopathy with potentially can cause also functional limitation and drug interactions in case of polypharmacy must be regarded -In case of statin intolerance ezetimibe or PCSK9 (proprotein convertase subtilisin/kexin type 9 ) inhibitors represent reasonable alternative treatment options. The gene discussed is PCSK9; the disease is Myalgia.