However, we observed that the plasma level of all Kyn metabolites were decreased by TTP administration accompanied with decreased gene expression of KatII/Aadat and Kynu. These enzymes are localized to mitochondria or both mitochondria and cytosol [30, 31], and it is possible that the decreased level of Kyn metabolites are associated with decreased mitochondrial function and/or induced fatty liver. The gene discussed is KYNU; the disease is fatty liver disease.