The mechanical deformation of tissues and mechanical stress influence intracellular signaling by mechano-sensors like PTK2 [101] or YY1 associated protein 1 (YY1AP1)/tafazzin (TAZ) [102], which are discussed as one drug resistance mechanism for BRAF-mutant melanoma cells [38, 49, 103] or progression marker for cutaneous and G protein subunit alpha q (GNAQ) mutant uveal melanoma [104–106]. Here, YY1AP1 is linked to melanoma.