The genes encoding several components of the DNA replication machinery like DNA polymerase delta (POLD1, POLD2), DNA polymerase epsilon (POLE), and those encoding components of replisome like CDC45, MCM2, MCM5, MCM7 were among the genes downregulated upon miR-193a expression in the medulloblastoma cells. The gene discussed is MCM2; the disease is medulloblastoma.