To explore the clinical value of SCC antigen levels in guiding patients in selecting a treatment plan, evaluating the sensitivity of NACT, and predicting postoperative survival, this retrospective study compared the serum SCC antigen levels between patients with cervical squamous cell carcinoma who underwent NACT followed by radical surgery and those who underwent radical surgery alone, and an correlation analysis between SCC antigen levels and chemosensitivity, lymph node metastasis, and prognosis (overall survival [OS] and progression-free survival [PFS]) was conducted. Here, SERPINB3 is linked to metastatic malignant neoplasm in the lymph nodes.