In addition to the inconsistent cutoff values of SCC antigen levels that are used to predict lymph node metastases or to diagnose recurrence in different studies [20–22], further assessment of whether the SCC antigen levels could be usedfor guiding NACT before radical surgery and the identification of the optimal cutoff value of SCC antigen levels are still significant for the diagnosis, prognosis and treatment of cervical squamous cell carcinoma. Here, SERPINB3 is linked to cervical squamous cell carcinoma.