Moreover, overexpression of the soluble form of CX3CL1 has been shown to mitigate neurodegeneration induced by overexpression of alpha-synuclein in a model of Parkinson’s disease, and has also been shown to reduce tau phosphorylation and improve cognition in a model of tauopathy [11, 19, 20]. The gene discussed is CX3CL1; the disease is tauopathy.