STAT3 and cancer: Subsequently, the top ten hub genes were identified including TP53, UBC, RPS27A, MYC, HSPA8, MAPK1, CDC42, STAT3, PTEN, and PPP2R1A. Functional analysis of KEGG pathways presented that hub genes were mainly enriched in several important signaling pathway such as pathways in cancer, central carbon metabolism in cancer, proteoglycans in cancer, MAPK signaling pathway, sphingolipid signaling pathway, PI3K-Akt signaling pathway, microRNAs in cancer, colorectal cancer, TGF-beta signaling pathway and FoxO signaling pathway.