Oral administration of PLGA/PLA–PEG‐FA nanoparticles loaded with the ginger active compound 6‐shogaol (NPs‐PEG‐FA/6‐shogaol) in a colitis model significantly mitigates colitis symptoms and accelerates colitis wound repair by modulating the anti‐inflammatory factors nuclear factor erythroid 2‐related factor 2 (Nrf‐2) and heme oxygenase‐1 (HO‐1), and the inflammatory cytokines TNF‐α, IL‐1β, IL‐6 and iNOS. Here, IL1B is linked to colitis.