Exosomes obtained from MSCs of human umbilical cord significantly attenuate IBD by upregulating levels of IL10 and IFN‐γ inducible protein‐10 (IP10), while downregulating IL‐1β, TNF‐α, IL‐6,ubiquitin‐conjugating enzymes (E2M), NEDD8‐activating enzyme E1 (NAe1), and ubiquitin like modifier activating enzyme 3 (Uba3). The gene discussed is IL1B; the disease is inflammatory bowel disease.