AKT1 and neoplasm: Meanwhile, Baba et al demonstrated that hypoxia‐induced ANGPTL4 expression was regulated by HIF‐1α in scirrhous GC cells and was essential for tumor growth, metastasis, and resistance to anoikis through different mechanisms, including downregulation of c‐Myc and focal adhesion kinase (FAK)/Src/phosphoinositide 3‐kinase (PI3K)‐protein kinase B (Akt)/ERK pathway, upregulation of p27, and apoptotic factors caspases‐3, −8, and −9.47