Overexpression of ANGPTL2 has been reported in diffuse gastric adenocarcinoma compared with normal gastric tissue, according to Chen26 (FC = 2.239) and DErrico's (FC = 2.360) dataset, while ANGPTL2 was also upregulated in gastric cancer (FC = 2.249) according to Wang's dataset.27 Here, ANGPTL2 is linked to diffuse gastric adenocarcinoma.