In vitro and in vivo OSCC models showed that ANGPTL3 knockdown arrested cell cycle at G1 phase through upregulating cyclin‐dependent kinase inhibitors, thus reduced cancer cell proliferation and growth39 Nonetheless, in HCC cells, ANGPTL3 inhibited cell proliferation and invasion through downregulation of p38MAPK and MMP‐9 cascade's activation.40 This evidence concerns the gene MMP9 and hepatocellular carcinoma.