ANGPTL2 also strengthened responsiveness of BC cells to chemokine (C‐X‐C motif) ligand 12 (CXCL12) by the upregulation of C‐X‐C motif receptor 4 (CXCR4), thus promoted these cells’ recruitment to bone metastatic sites.35 The gene discussed is CXCR4; the disease is breast cancer.