NFE2L2 and metabolic dysfunction-associated steatohepatitis: Therefore, because Nrf2 is critical for mitochondrial homeostasis, lipid metabolism, and overall hepatoprotection,[21] the effects of omaveloxolone and a closely related analog, TX63682, were investigated in the STAM mouse model of NASH.[22] Diabetes and obesity are key features of the STAM model, which has been described to recapitulate the known progression of the human disease.[23] Structures of omaveloxolone and TX63682 are presented in Figure 1A.