The most interesting data showed that most SSNVs shared by sarcomatoid and carcinomatous tumors had already been identified in ccRCC genes, including SET domain containing 2 (SETD2), polybromo 1 (PBRM1), von Hippel–Lindau tumor suppressor (VHL) and phosphatase and tensin homolog (PTEN) (Bi et al. 2016). The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.