Neumann Neumann M M Sampathu Sampathu DM DM Kwong Kwong LK LK Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science Science 2006 2006 314 314 5796 5796 130 130 133 133 10.1126/science.1134108 10.1126/science.1134108 17023659 17023659. The gene discussed is TARDBP; the disease is frontotemporal dementia.