Although, the mutations in PTCH1, TP53, and TERT promoter have been reported earlier, this is the first communication to report alterations in those loci and the DPH3 promoter simultaneously in BCC tumors and to describe methylation levels within the THOR and transcription of the telomerase reverse transcriptase subunit23–25. The gene discussed is PTCH1; the disease is skin basal cell carcinoma.