Although, the mutations in PTCH1, TP53, and TERT promoter have been reported earlier, this is the first communication to report alterations in those loci and the DPH3 promoter simultaneously in BCC tumors and to describe methylation levels within the THOR and transcription of the telomerase reverse transcriptase subunit23–25. This evidence concerns the gene DPH3 and skin basal cell carcinoma.