The more CD4+ T and CD8+ T-cell populations were found in the splenocytes isolated from the tumor-bearing mice treated with rClone30-Anh(F) or rClone30-Anh(HN-F) and the unpublished data showed rClone30-Anh(F) or rClone30-Anh(HN-F) treatment downregulated the immunosuppressive factor, which suggest that chimeric viruses expressing the F gene of lytic strain Anhinga can circumvent immune suppression and enhance the systemic antitumour immunity (Fig. 8). The gene discussed is CD4; the disease is neoplasm.