In addition, during viral infection, the binding of the HN protein to its cognate receptor, cellular sialic acid, causes a conformational change that facilitates the specific homotypic interaction between F and HN, triggering fusion of the viral envelope with the host cell membrane [52] indicating that the interaction of homotypic HN and F proteins of paramyxoviruses is important for the proper function of these proteins. The gene discussed is MT-RNR2; the disease is viral infectious disease.