IHC staining from these ccRCC xenograft tumors also demonstrated that combining the ICI 182,780 and sunitinib resulted in better decreases of the expressions of ERβ, ANGPT-2, CD31 related angiogenesis marker37, and CD34 related VM marker38 (Fig. 7g), which is consistent with our in vitro findings. This evidence concerns the gene ANGPT2 and nonpapillary renal cell carcinoma.