ESR2 and nonpapillary renal cell carcinoma: Together, results from human clinical sample analysis suggest that a higher ERβ expression was associated with the poor prognosis in ccRCC patients (Fig. 2a–c), which is in agreement with the above in vitro data from multiple ccRCC cells showing higher ERβ may function via up-regulating the HUVEC tube formation to alter the sunitinib sensitivity to promote the ccRCC progression.