PK/pharmacodynamic modeling and simulations of ORR and serum M-protein (a surrogate for tumor growth) showed better efficacy with a deeper response in terms of serum M-protein reduction at dose 20 mg/kg compared with 10 mg/kg, and 20 mg/kg was subsequently chosen as the optimal dose for single agent isatuximab [31]. This evidence concerns the gene MYOM2 and neoplasm.