CD38 and hematologic disorder: Furthermore, PK data from a Phase 1 study of isatuximab in patients with RRMM or other CD38-positive hematologic malignancies indicate that, at 10 mg/kg Q2W, Cycle 1 plasma trough levels of isatuximab are consistently above the lowest pharmacological active dose in mouse tumor models (10 μg/ml), and at dose 20 mg/kg Q2W, Cycle 2 trough levels are above the concentration needed for tumor eradication (129 μg/ml) [32].