Interestingly, we found that low levels of EHD2 transcripts were significantly associated with increased MFS (Fig. 5b; p = 0.027) Multivariate analysis using a Cox proportional hazard model assessed the predictive value for MFS of the significant parameters on univariate analysis, that is, tumor size, SBR histological grade, lymph node status, age and EHD2 low or high expression. The gene discussed is EHD2; the disease is neoplasm.