Ubiquitinated, phosphorylated, and acetylated-TDP-43 aggregates were, in fact, identified in 95–97% of patients affected by amyotrophic lateral sclerosis (ALS) and in about 50% of Frontotemporal Lobar Degeneration (FTLD)1,5,6. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.