SOD1 and amyotrophic lateral sclerosis: SPB was shown to extend survival and motor performance in transgenic ALS SOD1 animal model, and these effects were attributed to an upregulation in the expression of nuclear factor κB (NF-κB) and bcl-2 proteins41, although the genetic inhibition of NF-κB in SOD1 mice does not ameliorate disease onset and progression59.