As shown in Supplementary Fig. 7, infection had no impact on adipocytes’ viability (Supplementary Fig. 7a), and resulted in increased levels of viral RNA (Supplementary Fig. 7b), nuclear and nucleolar changes featuring efficient viral genome replication, and budding of empty particles (Supplementary Fig. 7c), as well as increased expression of the antiviral innate-immune-related genes Tlr3, RigI, Mda5, Mx1, and Vip (Supplementary Fig. 7d). Here, TLR3 is linked to infection.