PSPH and infection: Indeed, the IAV-infection-gene-signature in preadipocytes includes several genes encoding enzymes within the SGOC pathway, such as the cytosolic phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH) and serine hydroxymethyltransferase (SHMT) 1, and the mitochondrial SHMT2, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) and MTHFD2 (Fig. 7b).